Primary immune deficiencies

Defects in B cells and T cells

B cell immune deficiencies
Agammaglobulinemia

Hyper IgM (HIGM) = B cells cannot class-switch because Common variable immune deficiency (CVID) = B cells cannot differentiate into plasma cells
 * Deficiency in AID enzyme
 * Deficiency in CD40 or CD40L

Most patients are diagnosed in their 30s or 40s.