Mutation

Missense

Nonsense

Framework

Insertion

Deletion

Loss-of-function mutations
Amorphic (null) = complete loss of gene function

Hypomorphic = partial loss of gene function, as result in reduction in gene expression or reduced protein/enzyme performance

Haploinsufficient = haploid dose of gene not sufficient for normal gene function

Antimorphs, a.k.a. dominant negative = oppose normal activity; dimeric protein consisting of one normal and one mutated protein no longer functional